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It has been reported that sustained ERK1/2 activation is integrin-dependent [13] upon FGF stimulation.
Recently, it has been reported that sustained ERK activation was involved in calcium-induced apoptosis of lens epithelial cells [46].
It has been reported that sustained ERK1/2 activation is integrin-dependent and crucial to cell cycle entry upon FGF stimulation.
It has been reported that sustained exposure to high levels FVIII induces apoptosis of FVIII-specific BMEM in haemophilia A mice in which anti-FVIII Abs were induced (Hausl et al, 2005).
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In addition, it was reported that sustained ERK activation and related cell cycle progression in the IGF-1 receptor pathway is mediated by β-arrestin1 [9].
In the literature, a case of PLO was reported that sustained fractures in eight vertebrae [ 8].
Recently, it was reported that sustained activation of the JAK-STAT cascade was involved in hepatocarcinogenesis and metastasis [ 52, 53].
In 1988 it was reported that sustained UC over a period of 8 10 years significantly increases the risk of CC by 0.5 1% [ 2].
Previous studies have observed abnormal Ca2+ handling in CMs from mdx mice (Williams and Allen, 2007; Yasuda et al., 2005), and it has been reported that the sustained elevation in Ca2+ levels through L-type Ca2+ channels precedes cytochrome c release from the mitochondria during cell apoptosis (Boehning et al., 2003; January and Riddle, 1989).
It has been reported that Dia sustains apical tension during differentiation in the pupal eye disc.
The opposite has also been reported, that receptor endocytosis serves to ensure sustained signaling.
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