Sentence examples for been reported that statins from inspiring English sources

Interestingly, it has previously been reported that statins can down-regulate the levels of the CCR5 chemokine receptor on both B and T lymphocytes [15] CCR5 has been shown to be present in cholesterol rich lipid rafts, co-localizing at the leading edge of migrating cells [16].

It has been reported that statins decrease total LDL level [ 28].

Although it has been reported that statins could improve liver steatosis and reduce the NAFLD activity score [ 14], their efficacy against fibrosis remains unclear.

It has been reported that statins prevent the incidence of steroid-induced osteonecrosis and the enlargement of bone marrow adipocytes in rabbits [ 26].

Moreover, it has been reported that statins show inhibitory effects on TGF-β-induced [ 9], vitamin D3 and warfarin combination therapy-induced [ 8], and inorganic phosphate-induced [ 6] trans-differentiation of cultured vascular smooth muscle cells, which is considered to reflect vascular calcification.

It has been reported that statins, estrogen replacement therapy, and a low fat/high carbohydrate diet lower the LDL-C content in LDL particles more than they lower the LDL-P concentration, while fibrates, nicotinic acid, exercise and a low carbohydrate diet lower LDL-P concentration more than they lower LDL-C content [ 3].

However, it has been reported that statin treatment with lowering LDL-C level has little or no effect on all-cause mortality, cardiovascular mortality, or cardiovascular events in individuals receiving dialysis [ 31].

In contrast, it was reported that statins increased BMPER mRNA expression via the Rho ROCK signaling pathway in HUVECs [ 24].

It was reported that statins inhibit in vitro calcification of vascular smooth muscle cells induced by inorganic phosphate [ 6], inflammatory mediators [ 7], vitamin D3 and warfarin [ 8], and transforming growth factor (TGF -β [ 9].

As dexamethasone is an approved prescription drug without boxed warning, it provides additional value for its application in CF. The employed testing strategy also predicted statins as interesting repurposing candidate and it was reported that statins retain ceramide levels normal in CF patients [ 78, 79].

36, 56 It has been reported that plasma statin concentration tends to be higher in people with the above polymorphism, thus predisposing them to adverse effects.