The temporal relationship between obesity and wheezing disorders in this study remains difficult to disentangle; however, in a recent Mendelian randomisation study by Granell et al, 44 it has been reported that obesity precedes childhood wheezing disorders.
As it has been reported that autophagy generally precedes apoptosis, one possible explanation may be that the stimulation of autophagy by SR1, ACPA, or GW or by their combinations with GEM is so elevated to inhibit the development of the apoptotic cell death program.
For home-based HIV testing, another provider-initiated testing strategy, it has been reported that the social mobilization that precedes testing increases acceptance and uptake of testing [ 18- 20].
Although forecasting an occurrence of phreatic eruption is very difficult, it has been reported that some precursory activities often precede these eruptions at several volcanoes.
It has been reported that apple fruitlet abscission is preceded by a stimulation of ethylene biosynthesis and an acquisition in the sensitivity to ethylene [ 12].
Interestingly, it has been reported that Rab5 regulates an early sorting step preceding axonal transport, while Rab7, a regulator for the endosome/autophagosome-lysosome fusion, regulates long-rage retrograde axonal transport in motor neurons [56].
It has also been reported that elevations in CRP may reflect events that may precede but ultimately lead to radiographic progression in osteoarthritis [ 25, 28].
It has been reported that alterations in the size and shape of cells precede cellular degeneration [ 49].
It is reported that epigenetic perturbations may precede, parallel or follow transcriptional perturbations and can be uncoupled from alterations in transcriptional activity [44].
It was reported that 99% of mechanical failures especially rotating machinery are preceded by noticeable indicators[4].
