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miRs are expressed at variable levels in diverse tissues and developmental stages [ 14, 15], regulate their own biogenesis [ 16- 18] and it has been reported that modest changes in miR level can result in substantial changes in the accumulation of mRNAs target genes [ 12, 19].
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Recently, it was reported that modest over expression of circulating adiponectin in LepOb mice completely rescued the diabetic phenotype in LepOb mice.
It has also been reported that even modest changes in the ADMA level can have significant effects on NO synthesis [31].
It has also been reported that a modest correlation exists between mRNA and protein levels [ 66].
It has been reported that a modest weight reduction achieved via caloric restriction resulted in a 13% deterioration in insulin sensitivity among a group of postmenopausal MHO women (2).
It has been reported that a relatively modest change in the overall energy density of the diet of a person consuming a consistent weight of food would significantly impact his or her daily energy consumption [ 56].
It has been reported that dSmad2 may play a modest role in the proliferation of wing cells, without affecting patterning and gene expression [13], [17].
It has been reported that the toxicity of AMPs can be reduced by modest sequence modifications (Kim et al. 2014).
It has also been reported that substantial weight loss reduces fibrinogen levels more effectively than modest weight reduction [ 53].
It was reported that lysozyme had only a modest DNA extraction efficiency for Gram-positive bacteria and a few Gram-negative bacteria (Yu et al. 2013).
Earlier this year, it was reported that the average cost of a modest home went over $400,000.
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