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It has been reported that moderate consumption of alcohol is protective against heart diseases [ 44], and a vital social activity for the elderly [ 45].
It has been reported that moderate to high percentages of adults seeking treatment for pathological gambling have comorbid alcohol and/or substance misuse disorders.
It has been reported that moderate hypoxia >10 mmHg increased [ 19, 46] or decreased [ 23, 47, 48] adipogenic differentiation and increased [ 10, 19, 47, 48] or decreased [ 20, 23] osteogenic differentiation of MSCs.
It has been reported that moderate or intermittent exercise training is associated with anti-inflammatory and beneficial effects on immunological functions like immune polarization toward Th1 lymphocyte [ 18– 20].
30 It has also been reported that moderate to severe Alzheimer's disease pathology in cortical biopsy specimen is associated with worse baseline cognitive performance and diminished postoperative improvement on iNPH symptom severity scales compared to patients lacking pathology.
It has been reported that moderate alcohol consumption has a positive association with HR-QoL in middle aged women [ 31]; therefore, we combined non-drinkers and occasional drinkers in a single group and presented the data for moderate alcohol consumption only.
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This finding is not surprising, since it has been reported that moderate-vigorous physical activity was independently associated with adiposity indices in children, while sedentary time was not [ 13].
It is reported that moderate alcohol consumption improves insulin sensitivity, an effect that may be mediated through inhibiting gluconeogenesis (28), increasing adiponectin plasma levels (29), promoting insulin production by the pancreas (30), and decreasing markers of inflammation (8, 31).
It was reported that moderate exercise had a beneficial effect on the function of in vitro NK cells in stomach cancer patients after curative surgery [ 18], and also in women with breast carcinomas [ 33].
It has been reported that, in moderate doses, beer may protect against thrombosis.
It has also recently been reported that at moderate altitude of 2340 m, the 15% increase in hemoglobin concentration induced by three weeks of acclimatization in athletes resulted in a progressive rise in CaO2 that was associated with a 8.9% increase in V̇O2max from acute to chronic exposure to 2340 m [28].
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