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It has been reported that melatonin participates in the regulation of a number of physiological and pathological processes [ 10].
Recently, it has been reported that melatonin influences cell growth and differentiation of neural stem cells (NSCs) [ 10, 11].
Recently, it has been reported that melatonin at millimolar concentrations reduces, both in vitro and in vivo, the growth of C6 glioma cells (Martín et al, 2006).
Also, it has been reported that melatonin can easily cross the blood-brain barrier and it is especially taken up via the choroid plexus [ 26, 27].
It has been reported that melatonin inhibits tumour growth in a variety of in vivo and in vitro experimental models of neoplasia (Cos and Sánchez-Barceló, 2000a, 2000b; Blask et al, 2002).
Besides of its widely documented action regulating the circadian rhythm, it has been reported that melatonin contributes to the reduction of oxidative damage in both the lipid and the aqueous environments of the cell (Aydogan et al 2006).
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It is reported that melatonin reduced serum total cholesterol and triglycerides [ 12] and may have therapeutic effect in fatty liver disease [ 12].
It was reported that melatonin application 15 min prior to UV-irradiation significantly suppressed erythema compared to treatment with vehicle alone.
Melatonin plays a role in synchronizing the reproductive responses of animals to environmental light conditions; it has been reported that serum melatonin levels during human pregnancy are higher than in a non-pregnant state [ 18].
It has been reported that the melatonin administration is associated with significant, dose-dependent increases in GABA concentrations in the central nervous system [ 10].
It has recently been reported that the sleep deprivation associated with overnight phase assessments can reduce melatonin amplitude by 6.7% [69].
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