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It has been reported that ethanol contributes to neuronal damage.
Little is known about the neurological basis for hyperalgesia induced by ethanol withdrawal, but it has been reported that ethanol can potentiate the response of transient receptor potential vanilloid receptor-1 (TRPV1) in superficial tissues.
It has recently been reported that ethanol can cause cholinergic imbalance (Jamal et al., 2007).
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It was reported that ethanol plays a dramatic role as a repressor preventing the induction of specific enzymes needed for xylose utilization in P. stipitis and when ethanol concentration was greater than 30 g/L, induction of xylose reductase (XR) and xylitol dehydrogenase (XDH) was greatly decreased [ 11].
It has been reported that the ethanol extract of A. capillaris exerted an anti-inflammatory effect on the mRNA expression level of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 cells [ 31].
This finding suggests that B. rhizoxinica can take up citrate, malate, glycerol or ethanol during its intracellular life and it has been reported that Rhizopus produces ethanol and glycerol when grown on various sugars or wood hydrolysates [ 34].
Although it has been reported that long-term ethanol feeding reduces the severity of early atherosclerotic lesions in mice and ethanol inhibits human platelet activation and enhances endothelial fibrinolytic activity both of which are important for athrombogenesis [ 33].
It has been reported that 1% ethanol (EtOH) removes most epithelial cilia from the planaria Dugesia japonica; and although movement was not investigated in depth, it was noted that 1% EtOH did not paralyze worms [14].
Finally, it has been reported that hydrogen production is associated with ethanol production during microbial glycerol metabolism (Varrone et al. 2012).
It has been reported that the up-regulated genes in the presence of ethanol are commonly selected as targets for the construction of ethanol tolerant strains.
Interestingly, it has been reported that a high flux through PDH can increase ethanol yield [ 27].
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