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Interestingly, it has been reported that decreasing the stability of RNA structures within portions of the APP 5' UTR is correlated with increased expression [20].
Furthermore, it has been reported that decreasing SOD2 activity favors cell proliferation, while increasing SOD2 activity facilitates proliferating cells' transitions into quiescence through the modulation of cyclin expression [67].
An increased risk for severe disease associated with concurrent conditions may also explain the higher rate of initial hospitalization that we observed for persons in older age groups; it has been reported that decreasing immunity in the elderly is correlated with the presence of concurrent conditions (33, 34 ).
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Moreover, it has recently been reported that decreased IL-10 production is associated with a higher risk for relapse [ 33].
It has been reported that decreased p27 protein level is a negative prognostic indicator in human tumours including bladder cancer.
It also has been reported that decreased expression of p53 protein can lead to up-regulation of p16ink4a[ 17].
It has been reported that decreased numbers of dendritic cells (DCs) are correlated with poor prognosis in some types of malignancy, such as gastric cancer.
It has been reported that decreased ester-linked PCA/FA ratio is associated with increased forage digestibility in barley [ 54] and increased cellulose digestibility in switchgrass [ 55].
Accordingly, it has been reported that decreased ability of STAT3 to bind DNA precedes decreased Bcl-2 expression and induction of apoptosis (Nielsen et al, 1999), indicating the involvement of STAT3 in the transcription of Bcl-2.
More recently, it has been reported that decreased relative left-frontal brain electrical activity may be a trait-like marker of depression, suggesting that frontal asymmetry could also be a shared factor predicting first depression onset [ 41].
It has previously been reported that decreased activation of canonical Smad signalling in cells treated with both TGFβ and CCN2 is associated with increased non-canonical signalling by ERK MAP kinase [ 13].
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