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It has been reported that alteration of DNA methylation in hepatocellular carcinoma (HCC) evolves through precancerous lesions to multistage hepatocarcinogenesis [56].
It has been reported that alteration of the expression of ZIP transporters affects Zn distribution.
Recently, it has been reported that alteration in the microenvironment of melanocyte cells, such as substrate adhesion blockade, results in the selection of anoikis-resistant cells, which have tumorigenic characteristics.
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It has also been reported that alterations in photosynthetic activity and the absorption and distribution of essential nutrients lead to reduced plant growth.
It has been reported that alterations in the size and shape of cells precede cellular degeneration [ 49].
It has been reported that alterations of miRNAs in CD4+ T cells and Tregs are correlated with certain activation states and diseases [ 26- 28].
It has been reported that alterations in the APC gene are present in more than 80% of colorectal cancer cases [ 6, 7].
For instance, it has been reported that alterations in the TP53 gene have little or no influence on survival in patients treated with surgery alone, but were associated with worse survival for patients treated with chemotherapy (Iacopetta, 2003).
It has also been reported that alterations in glucose and lactate levels in synovial fluid are associated with ON of the femoral head, indicating that synovial fluid metabolites may be an effective method of monitoring the disease progression (Huffman et al. 2007).
However, it has been reported that alterations in microfibril periodicity can be induced by heritable mutations in the fibrillion-1 gene (FBN-1) [56], by modification of the in vitro environment such as via calcium chelation [57,58], reduced salt concentration [59] and also by adsorption to high surface energy substrates [38].
In addition, to altered gene regulation patterns in cancerous conditions, it is reported that alterations may exist in the carbohydrate structures attached to the protein backbone or in the protein backbone itself.
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CEO of Professional Science Editing for Scientists @ prosciediting.com