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It is not clear whether P2X4 is expressed ubiquitously in mammalian lysosomes, or restrictively in certain cell types, as has been reported in tissue distribution studies (Qureshi et al., 2007).
In fact, growth inhibitory actions attributed to on-target effects of PPAR ligands have been reported in tissue culture systems, and these results do not predict increased risk of carcinogenesis.
The increased secretion of angiogenesis-promoting factors, including VEGF, has also been reported in tissue microarray analyses of renal biopsies in patients with obesity-related glomerulopathy, whose glomeruli are markedly increased in size [ 71].
Brevetoxin, like other lipophilic agents, is likely to partition to cellular elements in blood, and brevetoxin immunoreactivity has been reported in tissue lymphocytes and macrophages of manatees poisoned by brevetoxins (Bossart et al. 1998).
Elevated lipocalin 2 (levelslevels has also been reported in tissue- and urine samples from patients with invasive breast cancer [ 37] and is proposed as a noninvasive biomarker for advanced breast cancer.
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Moreover, enhanced levels of STK35L1 transcripts have been reported in tissues obtained from colorectal cancer patients [19].
To our knowledge, deletion at chromosome 11q12, where RARRES3 is localised, has not been reported in tissues of colorectal carcinoma.
Tumor-specific CaD splice variants have been reported in tissues from patients with colon, urinary bladder, and prostate cancers [ 26].
Thus, a robust inflammatory response occurs in the brain white matter in cALD, whereas minimal or no inflammatory lesions have been reported in tissues from AMN patients (5).
In particular, an altered protein conformational state of p53, independent from point mutations, has been reported in tissues from patients with AD that led to an impaired and dysfunctional response to stressors [ 2- 4].
An altered conformational state of p53, independent from point mutations, has been reported in tissues from patients with Alzheimer's disease (AD), leading to an impaired and dysfunctional response to stressors.
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