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Many potential mechanisms have been reported in model systems but few of these have been confirmed as being associated with AI-resistance in the clinic.
An overall positive correlation between gene density and recombination rate has been reported in model plant Brachypodium distachyon.
Some of these genes might represent new cold-responsible transcripts which have not been reported in model plants.
A number of such genes have been reported in model organisms; for example, in Drosophila[ 3, 20] and in the mouse (Mus) [ 2, 21].
Identification of miRNAs has previously been reported in model plants, including in developing pollen of O. sativa[ 29] and mature pollen of Arabidopsis[ 30, 31] by using deep sequencing or miRNA arrays.
Similar findings have been reported in model species used in laboratory selection experiments (e.g. Atlantic silversides, Menidia menidia Munch et al. 2005; guppies, Poecilia reticulata Reznick and Ghalambor 2005).
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Sustained, enhanced non-oxidative glucose utilization has also been reported in models of ischemia-reperfusion [ 15].
Hypermotile cilia have not been reported in models, in contrast to observations in a significant minority of individuals with PCD.
This likely precludes observing the pro-tumor effects that have been reported in models of established tumors.
Good correlations between T1 relaxation and time and brain water content have been reported in models of brain edema [ 61- 63].
An altered GABA-A receptor function has previously been reported in models of inherited murine cerebellar ataxia caused by a mutation in the CACNA1A gene.
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