This merging strategy has been reported, in larger scale, in the evolution of Ontario telemedicine network that resulted from the merge of three independent regional networks [ 18].
Several novel computational methods for systems biology were proposed for the first time and some intriguing biological findings were reported in large scale experiments.
Approximately, 10% of the expressed genes we detected in NB4 cells at the protein level are exclusive to this study and have not been reported in large-scale proteomic studies of other human cell lines (listed in Supplementary file 2).
The association of the FTO variant with overweight was the same in East and South Asians (OR 1.13 per minor allele) and very similar to the effects (ORs ranging from 1.13 to 1.18) that have been reported in large-scale studies of white Europeans [ 1, 7, 47].
Similar results were reported in large-scale studies investigating copy-number variation between people [30].
For instance, negative genetic correlations (from −0.30 to −0.50) between milk quantity and Artificial Insemination (AI) success have been reported in a large scale study performed in HOL, NOR and MON [5].
The usefulness of the IASLC/ATS/ERS lung AD classification as a prognostic factor has been reported in several large-scale retrospective analyses [ 5– 7].
The characteristics of our patients and the clinical presentation of their HZ episodes are consistent with those that have been reported in other large-scale studies that have been carried out in developed countries [ 21- 27].
Abnormal hemostasis in cancer patients has previously been described, however the correlation between the plasma fibrinogen level and cancer metastasis and prognosis has not been reported in a large-scale clinical study.
Unlike what has been reported in other large-scale databases, our internal warehouse does not contain samples with truncating, nonsense mutations [ 23]; however we did uncover 29 rare, single nucleotide variants (SNVs) (Additional file 1: Table S1).
Three somatic, non-synonymous point mutations of TRKB have been reported in the early large-scale sequencing studies in human cancers: two in colorectal tumors, TRKBT695I and TRKBD751N [17], and one in a lung adenocarcinoma cell line, TRKBL138F [19].
