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In addition, miRNAs alterations have also been reported in circulating immune cells in type 1 diabetic subjects [ 3, 4].
Importantly, a similar loss of Bcl-2 has been reported in circulating lymphocytes of patients with sepsis (4 ).
Genetic and epigenetic alterations including point mutations, microsatellite instabilities (MI), losses of heterozygosity (LOH), and DNA hypermethylations have been reported in circulating DNA.
The WIF1 gene promoter hypermethylation has been reported in circulating DNA isolated from plasma of colorectal adenoma and CRC patients [ 31].
MCP-1 may inhibit CCR2 expression (20), and increased MCP-1 production has been reported in circulating or adhered monocytes from T1D patients at the mRNA or protein level, respectively (30– 30).
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However, a dissimilar trend has been reported in serum circulating CCNB2 mRNA, since it was found to correlate with both grade and metastasis status [ 28].
Three major populations of circulating B cells have been reported in peripheral blood: transitional, circulating mature naïve and memory B cells discriminated on the basis of relative distribution of the markers CD24 and CD38.
Renal disease has been associated with obese individuals, and increased TGF- β and glomerulosclerosis have been reported in patients with high circulating leptin levels [ 39, 40].
In addition, cases of non-vitamin D deficiency rickets have been reported in Gambian children with chronically elevated circulating FGF23 concentrations [8].
Acute increases in levels of circulating MVs have been reported in mechanical trauma and sepsis patients (1), but the relationship with clinical severity is unclear, due potentially to the complex dynamics of acute inflammation.
A fourth phenotype, Hp0 (i.e. no detectable circulating haptoglobin) has been reported in various African populations.
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