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Further, constitutive activation of NFκB has been reported in cell lines as well as tumor samples and is believed to be linked to tumor progression as well as drug resistance [25] [28].
While many potential beneficial treatments have been reported in cell or/and animal models, reliable pre-symptomatic/symptomatic biomarkers that can indicate the disease status and test the therapeutic efficacy are lacking.
Cleavage products of expanded ataxin-3 have been reported in cell, fruit fly and mouse models of SCA3 and in SCA3 disease brains [30] [33], but most of the described fragments are C-terminal portions of ataxin-3 containing the polyQ domain.
Glyceraldehyde oxidoreductase activity has been reported in cell extracts of T. tenax [ 5].
Although, in general, the spontaneous Thr696 phosphorylation is unchanged in smooth muscle tissues, moderate fluctuations have been reported in cell cultures and smooth muscle tissues under certain conditions.
An association between HER-2 and COX-2 expression in IBC has been reported in cell line (Vadlamudi et al, 1999; Subbaramaiah et al, 2002b), animal (Howe et al, 2002) and in human immunohistochemical studies (Ristimaki et al, 2002).
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Reduction in Bub3 mRNA has been reported in cells upon prolonged exposure to taxol, and been proposed as a cause to the mitotic slippage [11].
Inhibition of p38 MAP kinase by sorafenib has already been reported in cell-free kinase assays [ 20].
Markers typical of macrophages have been reported in cells within the intervertebral disc.
More pronounced actin accumulations have been reported in cells infected with C. caviae (Subtil, 2004).
In particular, receptor colocalization in lipid rafts and other membrane structures have been reported in cells [ 22- 24].
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