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However, specific immunological defects have not been reported for single mutant mice.
A significant relationship between virus genotype ratio and weight was not found, whereas this has been reported for single genotype infections (Cory et al. 2004).
Similar negative findings have been reported for single drug trials that target the ERK pathway in colon carcinoma [ 75], where mechanistic studies have shown that concomitant inhibition of other pathways, (i.e. PI3K-AKT) is more effective in these patients [ 76].
To our knowledge, this overall approach was first described by Gao at al., following upon work that had previously been reported for single TFs and/or using promoter motifs (Gao et al. 2004 and references therein).
Similar(56)
Failure-free survival, defined as the absence of relapse, non-relapse mortality or addition of another systemic therapy, has been proposed as a potential endpoint for clinical trials, but its use has only been reported for single-center studies.
Similar AKT-dependent results have been reported for single-agent rapamycin (Gera et al, 2004).
The major clinical development of gefitinib has been reported for single-agent therapy in recurrent NSCLC.
A greater dose-sparing potency of medetomidine compared to that of midazolam or acepromazine has been reported for single-use propofol [ 18- 21].
Response rates of 5%21%% have been reported for single-agent chemotherapy, with 5-fluorouracil (5-FU), in chemonaive patients (Wils and Bleiberg, 1989; Loehrer et al, 1994).
Much lower response rates have been reported for single-agent DTIC (range, 5 15%), thus suggesting that the combination of plitidepsin plus DTIC may indeed have had a synergistic antitumour effect.
High response rates (between 37% and 60%) have been reported for single-agent amrubicin in three Phase II Japanese studies conducted in a population with sensitive and resistant relapses (Kato et al, 2006; Kudoh et al, 2006; Onoda et al, 2006).
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