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On the other hand, E. casseliflavus and E. gallinarum have recently been reported as causative agents of clinical disease [ 13, 14].
Genes were classified as autosomal Disease Dominant (DD; n = 498) if a mutation in a single allele has been reported as causative of a genetic disorder, autosomal Disease Recessive (DR; n = 662) if mutations in both alleles are required for the disease phenotype, and Others (e.g. X-linked diseases) as described previously.
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It is therefore important that variants being reported as causative of cardiomyopathies are truly disease causing.
It is hoped that this approach will reduce the substantial number of variants being reported as "causative" of disease without having sufficient supporting evidence for that classification.
Thus, due to its rare nature, only recent identification, and probable previous misidentification, C. dubliniensis has only rarely been reported as the causative organism in endophthalmitis.
The organisms have been reported as the causative agents for a variety of clinical symptoms in human and animals [ 1, 2].
By reviewing the English medical literature, P. marneffei had been reported as a causative organism of IRIS in only 4 HIV-infected patients.
Although resident bacteria on the ocular surface, such as Staphylococcus aureus and Staphylococcus epidermidis, have been reported as the causative pathogens [ 10– 12], environmental bacteria such as Pseudomonas aeruginosa or Stenotrophomonas maltophilia can also cause infections [ 12– 15].
Additionally, penetrating foreign bodies have been reported as a causative factor in splenic abscess [ 5], and in one dog, splenic abscess was diagnosed intraoperatively and histopathologically 3 weeks following an abdominal trauma [ 6].
From researches on familial PD patients, several genes such as DJ-1, LRRK2, and α-synuclein [ 8, 9] have been reported as PD-causative genes.
Actinomyces spp. have been reported as one of the causative bacteria of anaerobic lung abscesses [ 5].
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