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In the pioneering work of Thorsteinson et al. Mo V Nb catalysts [1], have been reported as active for the partial oxidation of ethane to ethylene and acetic acid using oxygen.
Several of the brain regions found to be the most central and functionally connected are areas that have previously been reported as active during language tasks in imaging studies.
In nitrogen fixers, the oxidative pentose phosphate cycle has been reported as active.
The gemcitabine-docetaxel and gemcitabine-dacarbazine combinations have also been reported as active treatments in some histological subsets [ 6– 9].
PubChem drug-target data demonstrate that HSP90 targets have been reported as active in geldanamycin and its derivatives, while untested/unspecified for both puromycin and prostaglandin.
Furthermore, R. microplus serine proteinase inhibitors BmTIs from larvae have been reported as active inhibitors of trypsin, neutrophil elastase, plasmin and plasma kallikrein [ 40, 41].
Similar(54)
On the other hand, and surprisingly, 45 compounds (Additional file 4: Table S4) were reported as active in both screens.
For the agonist screen (AID 743053), there were 372 substances reported as active outcomes and 9070 substances as inactive outcomes from a total of 10,486 substances, while for the antagonist screen (AID 743063), 670 substances were reported as active and 7770 substances as inactive from the same compound library.
It also acknowledges that mobile users that have automatic updates may be reported as active when they are not.
Out of the initially 326 FXR ligands from ChEMBL, only unique ligands that were reported as active (EC50 <100 μM) were kept.
Similar discrepancies have been demonstrated towards human chronic myelogenous leukaemia K562 whereas on one hand BE is reported as active, IC50 value 14.5 μM [ 25], while on the other hand it is completely inactive, IC50 values >200 μM [ 26] and 250 μM [ 35].
More suggestions(16)
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been reported as poor
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been reported as useful
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been suggested as active
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been deemed as active
been deployed as active
been reported as potential
been claimed as active
been discovered as active
been described as active
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CEO of Professional Science Editing for Scientists @ prosciediting.com