The −1154 G/A, −460 T/C, and +405 G/C VEGF polymorphisms have been reported as functionally relevant and associated with an increased risk of development of various inflammatory or neoplastic processes [ 16, 26].
Since CA9 has been reported to functionally mediate tumor growth and metastasis [ 35], we investigated the relationship of CA9 and cyclin E expression in esophageal cancer.
Even though the functional significance of the different JNK isoforms in human cells is far from clear, JNK1 and JNK2 have been reported as functionally distinct.
p53 and Sp1 families of transcription factors have been reported to physically and functionally interact in the induction of cell-cycle arrest and proapoptotic genes [ 16].
In correspondence with an RA-induced profile in CD34+ cells from CAD patients, these cells showed a concomitant higher expression of the transcription factor GATA2, which has been reported to functionally cooperate with RARα in embryonic stem cells [ 29].
These variants exhibit diverse structural configurations and have been reported to be functionally nonequivalent.
KLF4 and RELA have been reported to be functionally intertwined, as they directly interact to induce expression of selected genes [ 58], but also to compete for interaction with a co-activator, thereby inhibiting each other's activity [ 59] (Additional file 12: Figure S5).
First, the anterior and posterior insula have been reported to be functionally segregated regions with different connectivity [16 18]; however, we could not differentiate these subregions because of the constraint of the Colin27 anatomical labeling template.
PKP2 has been reported to be functionally related to sodium channel, and decreased in PKP2 expression leaded to downregulation of sodium current in cardiomyocytes of human [ 62, 63].
CD146 has been reported to be functionally relevant for endothelial cell adhesion and angiogenesis (Solovey et al. 2001; Yan et al. 2003).
