The paradigm of the RAP-to-CP sequence seen in genetic disorders such as hereditary pancreatitis has been replicated in population-based epidemiological studies of non-genetic etiologies, such as alcoholic AP and idiopathic AP.
Pilots of FOBt screening in the UK have demonstrated that screening is feasible and acceptable and measures of uptake, test performance and outputs seen in randomised controlled trials can be replicated in population screening.
However, our findings on eNOS, iNOS and VEGF haplotypes must be replicated in populations with different genetic backgrounds, which will further validate the role of these candidate genes associated with migraine and aura and may provide clinically relevant information to migraine susceptibility.
However, considering the distinct linkage disequilibrium patterns in European and other ethnic populations, it would be of tremendous interest to determine whether such associations could be replicated in populations of other ethnicities, such as Asians.
Candidate gene studies reported the association of a functional CD40 polymorphism with Graves' disease; moreover, the association of this variant was replicated in populations of different ethnicity including Caucasians, Koreans, and Japanese [2] [4].
Moreover, results from non-representative populations have to be replicated in population-based studies.
However, before recommendations based on this result can be made, it must be replicated in population-representative samples using objective measures of physical activity.
These analyses show that developed approach has predictive power, and that joint influence of longevity SNPs on life span can be replicated in populations of genetically independent individuals.
The association at rs2046210 has been replicated in European populations [ 67] but not in African populations, and other SNPs have not yet been studied.
Their small, localized successes have not yet been replicated in large populations.
These findings have been replicated in several populations around the world in both sexes – also within the Nordic countries [3] [9].
