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These findings have been replicated in mice who have undergone ovariectomies to mimic the low circulating estrogen state and have been further extended to show that an underlying molecular explanation for the reduction in force generation involves myosin.
Similar results have been replicated in mice fed high fat diets during gestation and lactation.
However, this model has proved very difficult to reproduce and the data has not been replicated in mice, rats or primates, in which only a partial response to proteasomal inhibitors is obtained [ 88].
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This thickened, coarse hair phenotype is replicated in mice genetically modified to undergo increased Edar signalling [23].
Surprisingly, the reported clinical pharmacokinetic interaction between sorafenib and docetaxel (Awada et al, 2012) could not be replicated in mice.
Similarly, positive results in the SCA may not be replicated in mice due to the inherent differences between a cell and animal model.
The characteristic features of human COPD including neutrophilia, the accumulation of macrophages and T-cells, production of cytokines, chemokines and proteases, oxidative stress, small airway fibrosis/remodelling, mucus hypersecretion, lung dysfunction and the development of emphysema can all be replicated in mice by exposure to cigarette smoke.
Although the mutation has been identified in only two people, the power of the research stems from the fact that the shortened sleep effect was replicated in mouse and fruit-fly studies.
Differentiation was associated with increased NFκB and IL8 response to TNFα, a finding that was replicated in mouse ESC [18].
These findings have been replicated in the mouse menstrual-like model (Xu et al., 2013).
These results have been replicated in a malaria mouse model, Plasmodium chabaudi, where one quantitative trait locus for resistance to malaria has been mapped in homologous regions of human 5q31-q33 [31].
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