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Their small, localized successes have not yet been replicated in large populations.
These findings have been replicated in large observational studies [ 85, 86], confirming the trial findings and cost effectiveness [ 87] of IV rtPA in clinical practice.
This highly correlated 2-factor model has also been replicated in large samples of substance abusers (r =.81) and adult outpatients (r =.75).
These loci including 6q23, TRAF1/C5, STAT4, IL2RB, KIF5A, PRKCQ, IL2/IL21, CD226, CCL21, CD40, CTLA4 and IL2RA, defined by single nucleotide polymorphisms (SNPs), have subsequently been replicated in large independent panels of patients and healthy controls.
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Thus, the present results should be interpreted with caution until these findings have been replicated in larger samples.
[38] However, this association has not been replicated in larger patient cohorts of different ethnic origin and the phenotypic consequences are unknown so far.
79 This has since been replicated in larger cohorts.
These results have not yet been replicated in larger studies [ 63– 63].
More recently, these findings have been replicated in larger RA cohorts from different centers [ 28- 30].
However, these studies were small, noncontrolled and their findings have not been replicated in larger randomised controlled studies.
However, these findings have not been replicated in larger trials and some concerns have been raised about the role of CoQ10 deficiency in the pathogenesis of SIM.
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been validated in large
been proven in large
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been conducted in large
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been demonstrated in large
been identified in large
been investigated in large
been applied in large
been observed in large
been replicated in numerous
been described in large
been replicated in different
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