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Hydroxycitric acid has been shown to prevent laboratory animals from gaining weight, but that result has not been replicated in humans.
One, Douglas A. Melton of Harvard University, said he had become aware recently that the White House was trying to reach out to some of his colleagues who are pursuing the skin cell research, which has not been replicated in humans.
These data have recently been replicated in humans following endovascular renal denervation [ 6].
30 However, these studies have been contradicted in other animal studies, 31 32 33 34 and have not been replicated in humans.
Notably, these findings have not been replicated in humans since no suppressive effect on systemic RAS has been found in patients treated with vitamin D [ 82] and in essential hypertensives after short-term calcitriol administration and after long-term cholecalciferol therapy [ 83].
Studies in a rat model suggested evidence for sex-differentiated effects of an insertion-deletion in the ACE gene with hypertension, a result which has now been replicated in humans [Higaki et al., 2000; O'Donnell et al., 1998; Stankovic et al., 2002].
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These findings have been replicated in human brain tissue collected during epilepsy surgery [ 15– 17, 20, 21].
127 128 These findings appear to have been replicated in human studies.
Unfortunately, avoidance of lung injury by HFOV in animal studies has not been replicated in human preterm infants.
It is somewhat disappointing that successful experimental inhibition of NFκB in animal models has not yet been replicated in human diseases.
The authors caution that a "big if" remains over whether the findings would be replicated in humans – and whether cognitive deficits as well as visible symptoms of the disease would be improved.
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