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EVOLUTIONARY theory predicts low equilibrium genetic variation for fitness and fitness-related traits, because alleles that have negative effects on fitness should have been removed by selection, whereas those with positive effects should have reached fixation (Fisher 1958; Falconer 1981; Charlesworth 1987).
Since the flanking sequences appear to be evolving largely at a neutral rate, the most plausible explanation for the observed decrease in SNP density is that about 35% of the mutations that occur in CSSs are harmful and have been removed by selection.
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Alternatively, globally distributed inversions could operate to promote reorganization of pseudogenes, but those not retained within the cluster are removed by selection.
If they were also detrimental early in life, they would be removed by selection.
These data suggest once again that most of the indels present in protein-coding genes were removed by selection.
These data suggest once again that most of the indels in protein-coding genes were removed by selection.
If selection is strong, deleterious and beneficial mutations are expected to make little contribution to polymorphism; deleterious mutations are removed by selection and beneficial mutations reach fixation rapidly.
If this CNV allele is generated (again by unequal crossover) as frequently as it is removed by selection, then it will be continuously present among CNV alleles.
If IRs at deleterious sites are removed by selection, an abundance that is concentrated at the sites where they are not deleterious would result.
Slightly deleterious gene loss events will take time to be removed by selection, and hence a larger proportion of them will be maintained between closely related genomes.
Almost all indels (34/37) occur in intergenic regions (table 1), suggesting that most indels in protein-coding genes were removed by selection.
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