Although the general concept of species divisions for bacteria has been regarded as problematic, there are a number of species definitions that are meaningful in the context of human health and disease, and being able to use this information with 16S sequencing efforts is important.
Obtaining research subjects' consent has been regarded as problematic in some case reports, such as those containing pedigrees [ 8, 9] or involving individuals with a questionable capacity to give consent, such as children and people with mental disorders [ 10].
Furthermore, for a young audience accustomed to the quick rhythms of MTV, a story in operatic form was regarded as problematic.
"Ondine" has had long absences from the Royal Ballet repertory, perhaps because Fonteyn was so strongly identified with the role of the water sprite who enchants a mortal man, perhaps because its dense score by Hans Werner Henze was regarded as problematic.
Slums may be regarded as problematic by many, but the film-makers behind Slums: Cities of Tomorrow discovered close-knit communities in India, Morocco, New Jersey, France and Quebec that are built on resilience, resourcefulness and human connection – and often in the face of government regulation.
However, its complexity itself should not be regarded as problematic or even surprising, for that matter.
One might conclude that exposing subjects to risks is regarded as problematic only to the extent that it has the potential to harm them.
The test-retest and inter-rater reliability data analysed in the present study were collected from a single RCF, which could be regarded as problematic.
At first it is play, then one boy becomes too violent, accentuates what is allowed as play, with the consequence that he is regarded as problematic and is excluded from the group.
Specific, pre-defined outcome measures are generally seen as the traditional marker of quality, which means that research questions that focus on processes rather than on 'outcomes' may be regarded as problematic.
A syncretic combination of different theories, which might be regarded as problematic from a philosophical perspective alone, can be justified in the context of an empirical-ethical research project.
