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The most widely studied tissue markers in CRC are thymidylate synthase, microsatellite instability, p53, K-ras and deleted in colorectal cancer (DCC), but they have not currently been recommended in routine practice for determining prognosis or predicting response to therapy [ 4].
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These measurements, however, are too costly to be recommended in routine clinical practice [ 8].
Repeated testing of anti-CCP antibodies or RF in patients with IP does not improve prognostic value and should not be recommended in routine clinical practice.
Without further evidence of efficacy from controlled clinical trials, such testing cannot yet be recommended in routine clinical care for diabetes prevention.
However, although determination of this marker is recommended in the context of clinical trials involving alkylating agents, it cannot be recommended in routine clinical practice (Stupp and Hegi, 2007).
Health Related Quality of Life questionnaires are frequently used for research, however only recently has their use been recommended in the routine clinical management of pituitary patients.
In fact, even the inferior LPM palpation is difficult and it has not been recommended in the clinical routine examination for temporomandibular disorders (TMDs), since there is a high possibility of false-positive findings [ 22].
Ambulatory blood pressure monitoring is becoming increasingly more common in routine clinical practice and has been recommended in the United Kingdom for the routine diagnosis of hypertension.
None of the GP IIb/IIIa antagonists are recommended in the routine management of low-risk, troponin-negative patients in whom early angiography is not intended.
In addition to the FEV1, also MRC functional dyspnoea has proved to be useful in predicting outcomes in patients with COPD, thus MRC functional dyspnoea measurement is recommended in the routine handling and evaluation of these patients [ 1].
MRC functional dyspnea is now proven to be useful in predicting outcomes in patients with COPD and is recommended in the routine handling and evaluation of these patients [ 19].
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