Sentence examples for been recognized to regulate from inspiring English sources

While initially described as caspase inhibitors now IAPs have been recognized to regulate a multitude of other cellular functions including regulation of the immune response cell migration, mitosis and proliferation [ 43].

Indeed poly-ADP-ribosylation has been recognized to regulate different processes, including DNA repair, transcription, genome stability, and signaling.

Recently, noncoding RNAs, such as enhancer RNAs (eRNAs) and natural antisense transcripts (NATs), have been recognized to regulate genes expression by interacting with promoter.

46, 47 Additionally, GSH has recently been recognized to regulate important cellular functions beyond cellular redox balance such as DNA synthesis, gene expression, and repair of the radiation-induced DNA damage.

Src family kinases are signaling enzymes that have long been recognized to regulate critical cellular processes, such as proliferation, survival, migration, and metastasis [ 36]. c-Src has been shown to regulate VCAM-1 expression in various cell types [ 12, 37].

IAPs are overexpressed in a number of tumors and are recognized to regulate carcinogenesis at various stages.

However, because COX expression also occurs in subepithelial cells, which in general are recognized to regulate epithelial cells by release of a variety of humoral factors, we also considered the possibility that inhibition of COX in these cells might indirectly influence stromal-epithelial cell function to elevate PAI-1.

Vitamin D, apart from its well-known task to regulate calcium metabolism, has been recognized to influence innate and acquired immune reactions [4].

To date, a number of potassium channels belonging to the Kv1, Kv2 and Kv4 families of the Kv superfamily have been recognized to be regulated by SNARE proteins [27] [31], [46], [57] [60].

Rearrangements of the actin cytoskeleton have long been recognized to be regulated, not only by the RhoA/ROCK pathway, but also, often in a coordinated manner, by the myosin light chain kinase (MLCK): MLCK directly phosphorylates the myosin light chain, leading to actomyosin contraction and endothelial barrier disruption [ 165- 167].

These belong to the forkhead box proteins (FOX proteins) that were initially known as regulators of embryonic development and have now been recognized to play important roles in regulating the expression of genes involved in cell growth, proliferation and differentiation.