While mouse and human AQP4 are 93% homologous, it is recognized that small differences in amino acid sequences, e.g. single residue substitutions, in heterologous proteins can have important effects on MHC binding as well as TCR-mediated stimulation [24], [25].
It should also be recognized that small towns located nearer to major citites, such as those included in this study, are very different from small towns in more remote locations [ 25].
While it has been recognized that even small islands can sustain endemic and endangered species of vertebrates, such forests are also important sites for endangered or even undiscovered species of plants, as further exploration of the remote islands of Lau will undoubtedly confirm.
This was expected as it has been recognized that only a small proportion of the Staphylococcus aurues lineages do not produce beta-lactamases [ 23- 26].
It has long been recognized that sauropods evolved from the much smaller, gracile, and bipedal primitive sauropodomorphs, a paraphyletic assemblage of taxa previously known as 'prosauropods' [1], [4] [9].
In recent years, it has been recognized that covering the HPV types with a small risk may jeopardize the overall positive predictive value of the assay.
It has often been recognized that the height of protein molecules appears smaller than the real height when they are strongly adsorbed on substrate surfaces.
First, it was recognized that certain small molecules could inhibit the activity of protein kinases [ 23].
Randomized trials of LC screening by chest radiography performed in the 1970s [ 9, 10] failed to answer the question of efficacy of radiographic screening, likely due to methodological flaws [ 11]; however, the possibility was recognized that a small but important benefit from annual CXR could have been missed [ 12- 14].
