Sentence examples for been recognized that proinflammatory from inspiring English sources

This review focuses on the gene therapeutic strategies of restoring the cytokine balance and genetic synovectomy in animal models of RA, as summarized in Figs 1 and 2. In animal models of arthritis it has long been recognized that proinflammatory cytokines, particularly TNF-α and IL-1β, play important roles in the pathogenesis.

It has been recognized that a dynamic interaction between proinflammatory and anti-inflammatory response is present in this syndrome, which is balanced by as yet unknown mechanisms.

"They're recognizing that.

For these reasons, IL-32 has been recognized as a proinflammatory cytokine, and has been implicated in inflammatory disorders such as RA and inflammatory bowel disease [ 17, 18].

Nonneuronal glial cells have recently been recognized to enhance the proinflammatory milieu and facilitate the central processing of nociception [ 187].

Tumour necrosis factor (TNF -α has been recognized as a pivoTNF -αoinflammatory cytokine in several inflammatory diseases, including Crohass disease and rheumatoid arthritis.

Resistin has recently been recognized to act as a proinflammatory cytokine in humans.

Adiposity has been recognized to generate a generalized proinflammatory milieu (13, 21, 22), which can promote progression of autoimmune processes.

This may underlie the propensity of TRegs to convert to Th17 cells in the context of proinflammatory stimuli, a phenomenon that has only recently been recognized [ 74- 76].

Interestingly, even if extracellular MSU crystals present a major proinflammatory potential, they have been recognized as an endogenous danger signal useful to immunity [ 6].

The proinflammatory cytokine IL-1 has recently been recognized as a major contributor to localized adipose inflammation and IR (24, 39, 42, 45, 47).