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Interestingly, ubiquitin ligases (and posttranslational regulation in general) have increasingly been recognized as regulators of core components of the circadian clock [69], [70].
In particular, miRNAs have also been recognized as regulators of adipocyte metabolic integration, energy homeostasis, and differentiation (Table 8).
They have been recognized as regulators of gene expression by acting as RNA chaperones through binding of misfolded RNA thereby preventing transcription termination [ 25].
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Mitochondria are recognized as regulators of apoptosis, and their involvement in regulation of cancer progression and metastasis is currently gaining much focus.
MicroRNAs are increasingly being recognized as regulators of embryonic development; however, relatively few microRNAs have been identified to regulate cardiac development.
Intermediate filament proteins were initially thought to function solely for mechanical stabilization of cells but are more recently being recognized as regulators of signal transduction [ 6].
The condensin complexes are recognized as regulators of chromatin structure and topology during cell division, with condensin II maintaining activity during interphase.
Besides the well-documented roles of Fos and Jun proteins in oncogenesis, where these genes can function both as tumor promoters or tumor suppressors, AP-1 proteins are being recognized as regulators of bone and immune cells, a research area termed osteoimmunology.
Members of the RecQ family of DNA helicases have been recognized as important regulators of genome integrity from bacteria to humans (reviewed in [20]).
miRNAs are a novel class of non-coding small RNAs which have been recognized as global regulators of gene expression that control the key cellular processes such as growth, development and apoptosis [9], [10].
Certain Ca2+-dependent protein kinases have also been recognized as positive regulators [ 16].
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