It has recently been recognized as the receptor mediating hepatocyte-specific entry of hepatitis B virus and hepatitis delta virus.
In higher plants, besides the conventional phytohormones such as auxin and cytokinin, a group of small secretory peptides, namely the CLAVATA3/EMBRYO-SURROUNDING REGION-RELATED (CLV3/ESR, CLE) peptides, has been recognized as important players that are responsible for mediating cell-to-cell signaling.
Another hub in the network, TGFBR I has been recognized as one of the major contributors to diabetic nephropathy mediated by the TGFB-signalling pathway [83].
The BNST has long been recognized as an important structure that integrates and mediates emotional, cognitive, autonomic, endocrine and behavioral responses to stress [ 2, 6, 9, 10, 14, 20, 51, 53].
For decades, secondary contact between species mediated by incidental human transport or deliberate introduction has been recognized as potentially detrimental to native species [ 20- 23].
Littorina grazing has long been recognized as a driver of intertidal algal diversity [19], and recent experiments have demonstrated the general importance of algal species richness and identity in mediating primary productivity [24], [25].
Because CXCR4 has been recognized as one part of MIF receptor complexes [15], this study was designed to investigate whether GRK2 expression induced by high glucose is mediated by MIF-CXCR4 pathway.
Traditionally, β-arrestins are recognized as molecules that mediate the homologous desensitization and clathrin-dependent endocytosis of 7TMRs [5].
Thrombin is recognized as a new candidate mediating airway remodeling.
Free radical formation in heme proteins is recognized as a factor in mediating the toxicity of many drugs.
