Since we do not have negative data (escape variants), all discontinuous motifs extracted from these strains were classified as neutralized motifs, which were recognized as functional in neutralizing assays.
This indicates that numerous duplicated copies "on their way out" may still be recognized as functional genes by the bioinformatics approaches [ 35] and may still be expressed according to FlyAtlas data [ 39].
More recently, TEs have been recognized as important functional components of genomes.
We also identified a subset of TCRβ V gene segments that had not previously been recognized as having multiple alleles, whose functional status segregated in our cohort.
DE has been recognized as a disturbance of 'lacrimal functional unit', an integrated system comprising LGs, ocular surface, and sensory motor nerves that connect them.
Endophytes have recently been recognized as an unexplored biofactory of functional metabolites [ 3, 5] that have array of activities against existing and emerging new threats of biomedical concern.
Conservation across multiple species has been recognized as a key indicator of functional importance [ 27, 28], although PDE4 s are known to be temporally and spatially differentially regulated [ 14, 29, 30].
Enduring neglect has repeatedly been recognized as a poor prognostic indicator for functional independence following stroke (Denes et al., 1982; Fullerton et al., 1988; Kalra et al., 1997; Jehkonen et al., 2000; Cherney et al., 2001).
Diabetic encephalopathy has been recognized as a severe diabetic complication, with adverse functional and cognitive effects.
Regarding head and neck cancer the last decade has seen a growing interest regarding the health-related quality of life (HRQL) for these patients, and functional status have been recognized as important outcome variables in the evaluation of head and neck cancer treatment [ 4- 6].
