Sentence examples for been recognised to play from inspiring English sources

Even though the former have been recognised to play often the major role, by increasing the horizontal load and the overturning moment transferred to the foundation, both of them must be taken into account in the seismic design of foundations.

One of these adipokines, adiponectin, has been recognised to play a major role in the pathogenesis of the metabolic syndrome.

The plasminogen activator system has been recognised to play an important role in tumour growth and metastasis (Pollanen et al, 1991; Andreasen et al, 1997; Schmitt et al, 2000).

It was initially believed that PR was a useful diagnostic marker of estrogen receptor activity, but increasingly PR has been recognised to play an important biological role in breast homeostasis, carcinogenesis and metastasis.

Genetic factors have long been recognised to play an important role in Paget's disease [ 3- 6] and recent studies by our own group and others indicate that between 40 50% of instances of familial Paget's disease are caused by mutations affecting the ubiquitin-associated (UBA) domain of the SQSTM1 gene [ 7- 11].

It is recognised to play a role in the immune system.

In contrast, influenza virus is recognised to play a major pathogenic role during flu outbreaks in the winter-spring season.

Genetic factors are recognised to play a role in PDB and it is now possible to carry out genetic tests for research.

Geographic isolation between conspecific populations (e.g. between refugia) is recognised to play an important role in allopatric speciation (e.g. [ 11, 12]).

The role of tumour-stroma cross-talk is recognised to play a role in PDAC progression (Vonlaufen et al, 2008; Froeling et al, 2009, 2011; Kocher et al, 2009; Olive et al, 2009).

Therefore, we were interested to determine whether the effects of the NSAIDs on proliferation and apoptosis described above were associated with changes in the cellular content of cyclin D1 protein, which is recognised to play a crucial role in progression through the G1 phase of the cell cycle (Lukas et al, 1996).