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It has been recognised that alterations in lipid metabolism can lead to cancer, cardiovascular disease, diabetes, neurodegenerative disorders, immune function, pain, mental disorders and inflammation.
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It has long been recognised that an alteration in cellular metabolism is a fundamental phenotype of cancer (Warburg, 1956) including leukaemia (Boag et al, 2006), but debate continues as to the exact nature of the changes involved and their functional significance.
Furthermore, it has be recognised that cells containing DNA alterations caused by viral or chemical carcinogens do not progress to become cancerous until they are exposed to a second type of stimulus that often includes chronic irritants or inflammatory agents (Coussens and Werb, 2002).
Aristotle did not use this terminology, of course, and it should be recognised that he and the scholastics that followed him had few examples of combination, as opposed to alteration and generation and corruption, to draw on.
It is recognised that cooling systems need to be flexible.
It is recognised that cubical particles provide more realistic results.
It is recognised that coal is a porous solid.
However, it is recognised that variable density flow is a three-dimensional process.
We are recognising that joblessness is a crisis.
Recently, methylation has been recognised as an epigenetic alteration that leads to gene silencing in human cancer (Estellar, 2003).
Mutations, amplifications or other alterations of the MET gene have not been recognised, raising the possibility that an aberrant transcriptional regulation may play a critical role in gene activation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com