The majority of these patients were previously treated with (and were randomized to) conventional antipsychotics (N = 43), with smaller numbers for olanzapine (n = 14) and risperidone (n = 11).
Ten of these were randomized to conventional tidal volume, and two, to lower tidal volume mechanical ventilation (P = 0.01; χ2 test), leading to a relative risk of 5.1 (95% CI, 1.2 to 22.6) for developing lung injury.
Results of OPTIMA are published elsewhere [ 26]. 184 patients were randomized to conventional care alone and 368 to cinacalcet: demographic characteristics and baseline laboratory values were similar between the treatment groups.
Seventy-eight patients were randomized to conventional (Vt 10 to 12 ml/kg IBW, PEEP 5 cmH2O - n = 39) or protective (Vt 5 to 6 ml/kg IBW, PEEP 10 cmH2O - n = 39) mechanical ventilation.
In a study where patients were randomized to conventional therapy and then arthroscopically evaluated for severity of chondropathy, cartilage deterioration was observed in both control and HA groups, but was significantly less in the HA group as measured by an investigator overall visual analog score and the Société Française d'Arthroscopie (SFA) scoring system [ 10].
Upon entry into this double-blind study, patients were randomized to conventional methotrexate (MTX) treatment plus placebo (disease-modifying anti-rheumatic drug (DMARD)) or MTX in combination with adalimumab (DMARD + ADA); both regimes were given in combination with intra-articular triamcinolone injections.
In the trial, patients are randomized to either conventional chemoradiation treatment (60 Gy in 30 fractions) or metabolically adaptive chemoradiation, where FDG-avid tumor subvolumes receive an integrated boost dose to a maximum of 85 Gy in 30 fractions.
Sixty-three EAAS patients were randomized to IGDT or conventional therapy.
The patients were randomized to intensive (40 mL/kg/h) or conventional (25 mL/kg/h) treatment [143].
In a small cohort of 16 patients with severe sepsis; patients were randomized to tight glycemic control or conventional glucose levels; strict regulation of glucose levels resulted in enhancement of fibrinolysis, as measured by lysis index with ROTEM [ 39].
