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Although a great deal of effort has been put into studying the molecular mechanism of hypoxia stress on HIFα stabilization via posttranslational regulation [8], [23], [34] [36], it still remains unclear whether hypoxia affects overall VHL tumor suppressor function.
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Time was put into studying the cultivation of one of South East Asia's most intriguing Non-Timber-Forest-Product, the eurycoma longifolia or "pasak bumi" as it's known in Indonesia.
Tremendous research effort has been put into the study of plastic deformation mechanisms of metallic glasses (MGs) in an attempt to elucidate the origin of their high fracture strength.
In the past, tremendous amount of research effort has been put into the study of surface texturing, with an aim to investigate the underlying effect of surface texturing on tribological performance.
In the past twenty years, a lot of effort has been put into the study of regular spectral problems on time scales (see [16 23]).
Since then, many efforts have been put into the study of the electronic, thermal, and optical properties of CdSe NWs as well [25, 26].
Much subsequent effort has been put into bioinformatic studies and small- and large-scale screens to refine the exact sequence of this presumed C-terminal motif [ 5- 10], leading to several consensus sequences, with different degrees of refinement (e.g. Additional file 1; [ 1, 10- 12]).
On the other hand the existence of proper SAC control has been put into question by studies using XO female mice, which harbor one univalent X chromosome that cannot be properly attached and is segregated at random in meiosis I without causing a metaphase I arrest [8].
A spokesman for Mr. Kelly said that 16 of the 19 recommendations had already been put into practice, and that a major study on improving police firearms training would be finished within a month.
In metastatic disease little progress has been made, but during recent years much effort has been put into the development of better clinical study protocols, with stratification of patients to at least the most common histological subtypes, preventing the dilution of potential treatment efficacy when measuring results over the total heterogeneous group of STS.
Based on mitochondrial genome data, the monophyly of stony corals (Scleractinia) has recently been put into question [ 22], but more thorough studies employing alternative datasets have rejected this hypothesis [ 21, 52].
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