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Some of the latter had been proven to trigger alterations of the secondary metabolite composition produced in one and the same plant species [ 42- 46].
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BSP, which is mainly lying on the root surface in cementogenesis, has been proved to trigger the mineralization and enhance the adhesion and differentiation of cementoblasts [ 26].
Several transition metals adsorbed onto fine particles have been proved to trigger the generation of reactive oxygen species, in turn able to activate NF κB, one of the most important mechanisms involved in PM induced pulmonary toxicity [ 43].
Dubbed "co-rumination" by psychologist Amanda Rose, this sharing and revisiting of problems together is proven to trigger depression.
The monomeric apical domain of GroEL (mini-chaperone or mini-GroEL) was proved to trigger the in vitro refolding of rhodanase and cyclophilin A without GroES and ATP and had the activity of intact GroEL in vivo [ 12].
Although no variable has been proven to be a trigger of relapses in patients with IBD, stress has been described as one possibility.
By using genetically modified mouse embryonic fibroblasts, caspase-9 was proven to be indispensable for triggering LMP, but the exact mode of action remains elusive.
Blocking the activity of VHL would result in up-regulation of HIF-1α which is an attractive therapeutic strategy in certain diseases where triggering the hypoxic response is proven to be beneficial.
This is proven to work!
Furthermore, two well-known events in ER stress, such as XBP1 unconventional splicing and DDIT3/CHOP nuclear relocation, were proved to be triggered by UCB treatment, therefore providing additional experimental evidences.
Conversely, other SRE variants were previously proven to trigger complete splicing defects, such as BRCA1 c.5080G > T and BRCA2 c.93G > T, c.145G > T or c.470_474del [ 14, 47].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com