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Initially described as post-transcriptional regulators involved in development, two decades ago, miRNAs have been proven to regulate a wide range of processes in plants such as germination, morphology and responses to biotic and abiotic stress.
ABA is famous for its stress-related properties but it also has been proven to regulate many development and growth processes.
First, three proteins (MPKKK1/OsEDR1, MPK6, and MPK12/BWMK1) of the predicted cascades have been proven to regulate the rice response to Xoo; both MPKKK1/OsEDR1 and MPK6, which are predicted in the same cascade, negatively regulate the rice resistance to Xoo in the same rice line (Yuan et al. 2007; Shen et al. 2010, 2011).
Recently, miR-199a has also been proven to regulate ER stress in cancer cells by targeting GRP78.
A great deal of miRNAs were identified as tumor suppressors; some of these microRNAs have been proven to regulate chemosensitivity.
Chlamydomonas CO has a typical DBB zinc finger domain and a CCT domain in the C-terminal, which has been proven to regulate photoperiod.
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Phosphatidylinositol 3-kinase (PI3K /protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway has been proved to regulate the formation of autophagosome (Sui et al. 2014).
The MARHS2 is a well known MAR element that had been proved to regulate the β-like globin genes expression [29].
In the study of PPARδ knockout in adult mouse heart, PPARδ has been proved to regulate both SOD1 and SOD2 expression [60].
MiRNAs have been proved to regulate the expression of important targets in the DDR pathway.
Interestingly, miR-218 has been proved to regulate HMGB1 and suppress migration and invasion.
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been confirmed to regulate
been reported to regulate
been suggested to regulate
been discovered to regulate
been introduced to regulate
been proven to present
been proven to cause
been proven to work
been proven to reduce
been proven to do
been proven to increase
been proven to yield
been proven to improve
been proven to interfere
been proven to be
been proven to bring
been estimated to regulate
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com