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Phosphatidylinositol 3-kinase (PI3K /protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway has been proved to regulate the formation of autophagosome (Sui et al. 2014).
The MARHS2 is a well known MAR element that had been proved to regulate the β-like globin genes expression [29].
In the study of PPARδ knockout in adult mouse heart, PPARδ has been proved to regulate both SOD1 and SOD2 expression [60].
MiRNAs have been proved to regulate the expression of important targets in the DDR pathway.
Interestingly, miR-218 has been proved to regulate HMGB1 and suppress migration and invasion.
By using animal kidney injury models, most of these factors also have been proved to regulate kidney recovery as potential renotropic factors.
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Initially described as post-transcriptional regulators involved in development, two decades ago, miRNAs have been proven to regulate a wide range of processes in plants such as germination, morphology and responses to biotic and abiotic stress.
ABA is famous for its stress-related properties but it also has been proven to regulate many development and growth processes.
First, three proteins (MPKKK1/OsEDR1, MPK6, and MPK12/BWMK1) of the predicted cascades have been proven to regulate the rice response to Xoo; both MPKKK1/OsEDR1 and MPK6, which are predicted in the same cascade, negatively regulate the rice resistance to Xoo in the same rice line (Yuan et al. 2007; Shen et al. 2010, 2011).
A great deal of miRNAs were identified as tumor suppressors; some of these microRNAs have been proven to regulate chemosensitivity.
Recently, miR-199a has also been proven to regulate ER stress in cancer cells by targeting GRP78.
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