Sentence examples for been proposed that expression from inspiring English sources

It has been proposed that expression signatures indicative of activity status of pathways can be used to define specific molecular phenotypes that characterize individual tumors [ 5].

For instance, Cdkn2a/p16INK4A is a regulator of the cell cycle, and it has been proposed that expression of Cdkn2a is a biomarker of aging in multiple mouse tissues [ 32].

The roles of multiple functional RP isoforms in plants remain unclear although it has been proposed that expression of multiple RP genes from a single family may be necessary to accommodate high – or specific – translational needs in growing plant tissue; thus, RP genes copies under development regulation may be required in addition to those gene copies that are constitutively expressed [ 29, 49].

Compulsive checking may arise in response to obsessions that focus on threat and danger, although, recently, the opposite has been proposed – that over-expression of checking behaviour might drive the development of obsession, perhaps to rationalise or justify excessive, compulsive action [4].

Considering the identical trend between selection efficiency and conservation of alternative exons 8, it is proposed that expression of alternative exons 8 might be closely related with its conservation.

The link between expression level and sequence evolution is invariably detected across a broad range of model organisms, so it was proposed that expression level or, more precisely, the rate of translational events is the dominant determinant of the sequence evolution rate (Drummond et al. 2005, 2006; Drummond and Wilke 2008).

It is proposed that gene expression is therefore an evolutionary constraint on genome organization, although the effect is weak as gene clusters are found only slightly more often than by chance [ 55].

RCAS1 expression has been detected in uterine cervical cancer by Sonoda et al., and it has been proposed that this expression is related to tissue remodeling.

It has been proposed that the expression ratio of BAX/BCL2 (proapoptotic to anti-apoptotic molecules) is related to the sensitivity of cells to apoptosis (Eimani et al. 2014).

It has been proposed that CXCR4 expression may be a mechanism by which NB cells metastasise at specific sites [12], [21].

It has been proposed that MMP7 expression in the first steps of tumorigenesis will select cells with reduced sensitivity to Fas-induced apoptosis [29].