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The dicarboxylic acids malate and fumarate have been proposed as modifiers of ruminal fermentation and as an alternative to antibiotics [ 19, 16].
Although various host factors may influence or modify risk, such as parity [ 14], genetic factors have also been proposed as modifiers of risk, such as genetic variants of HRAS1 [ 15], the androgen receptor (AR) [ 16], the 5'UTR of RAD51 [ 17], and repeat length polymorphisms in AIB1 [ 18], not all of which have been replicated or substantiated in subsequent studies [ 19- 21].
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Several renal factors have been proposed as possible modifiers of periodontitis pathogenesis in this population.
Variants in the genes encoding voltage-gated potassium channel proteins KCNQ1, KCNQ4, and KCNE1 have also been proposed as candidate risk modifiers in more common disorders of the auditory pathway, e.g. in Menière's disease [ 9], in noise-induced hearing loss [ 10, 11], in age-related hearing loss [ 12], and in chronic tinnitus [ 13].
These markers have been related to cognitive decline and increased systemic inflammation has been proposed as a possible modifier between MetS and cognition [ 22].
Among the factors related to health disadvantage and vulnerability, high intakes of antioxidant nutrients has been proposed as an important potential modifier of air pollution impairment (Romieu et al. 2008; Villarreal-Calderon et al. 2010).
Grass is proposed as a rheology modifier, filtration control agent as well as an alkalinity control agent for a DF.
A number of other associations have been proposed such as IL-2 receptor, -α (IL2RA), and interferon-induced with helicase C domain 1 (IFIH1) genes (58) and KIAA0350 (59) and small ubiquitin-like modifier 4 (SUM04) (60).
An allosteric pH regulator, also referred to as a pH sensor or H+-modifier, has been proposed for NhaA and NHE1.
Recently, modifier genes have been proposed to explain early and severe polycystic kidney disease.
The variant was suggested to be a low-penetrance gene as described in the polygenic model but the possibility of a role as a modifier of as – yet unknown high-risk gene/s has also been proposed [ 7- 9].
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