Although there has been significant progress in elucidating the components and mode of TGF-β secretion, little is known about the fate of latent TGF-β after its association with the ECM, nor the final steps of TGF-β activation.
Over the past few decades, there has been substantial progress in elucidating the genetic determinants underlying the BP response to sodium intake, or BP salt sensitivity.
Since then, there has been considerable progress in elucidating how insulin could promote cell proliferation and survival.
Though there has been some progress in elucidating ATP release mechanisms of some mammalian cells types, release conduits and coupling signal transduction machinery remain larger elusive for leukocytes.
Over the past 25 years, there has been significant progress in elucidating the involvement of the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR cascades in promoting cell growth, regulating apoptosis, chemotherapeutic drug resistance and more recently, cellular senescence and aging.
In recent years, there has been marked progress in elucidating the molecular origins of NSCLC, better classifying histologic subtypes, and developing targeted therapies, prompting an increased understanding of NSCLC patients by histology.
In recent years there has been tremendous progress in elucidating how the axons of neurons seek out, recognize, and establish connections with their targets in the developing nervous system.
Although there has been much recent progress in elucidating angiosperm phylogeny, there are still many unresolved relationships that are critical to understanding the angiosperm evolution.
There has been much recent progress in elucidating their aetiologies and treatment.
During recent years, the first genomes of methylotrophs have been sequenced and significant progress in elucidating their metabolism has been made.
