Despite the fact that historically cell death associated with calcium ion perturbations has been primarily recognized as necrosis, recent evidence suggest that more complex cell death scenarios could be associated with changes in the concentrations of Ca2+.
Fibroblasts and myofibroblasts in the skin use α5β1 or αv integrins to bind to fibronectin, whereas collagens are primarily recognized by integrins α1β1, α2β1 and α11β1 and to a lesser extent by other receptors such as cell surface heparan sulfate proteoglycans (syndecans) or discoidin domain receptors (Table 2).
Translational science is primarily recognized as an important contributor to product development.
Microtubule-associated proteins (MAPs) are primarily recognized as cytosolic proteins that bind to tubulin and stimulate their polymerization.
The fibrillin peptide, to our knowledge, is the first identified autoantigen that is primarily recognized in polyarticular JIA patients.
Although it is primarily recognized as the master transcription factor in Th1 cell development, T-bet is now known to be expressed and have a key role in cells of both the adaptive and innate immune systems (Garrett et al., 2007, 2009; Lugo-Villarino et al., 2003; Szabo et al., 2000, 2002; Townsend et al., 2004), but it has no known role outside the immune system.
Not surprisingly, CDPKs were primarily recognized as signaling mediators, which perceive rapid intracellular changes of Ca2+ ion concentration, for example triggered by environmental stress cues, and relay them into specific phosphorylation events to induce further downstream stress responses.
Son of the world renowned meteorologist Vilhelm Bjerknes, Jacob Bjerknes is primarily recognized for his work in developing the theoretical cyclone model as part of the "Bergen School" during the 1920's.
Many invasive plant species in Europe are primarily recognized as agricultural or forestry weeds.
