SIRT3, predominantly located in mitochondria, has been primarily linked to the regulation of a variety of mitochondrial processes, such as β-oxidation, ATP generation, management of reactive oxygen species (ROS) and others (Giblin et al., 2014).
Therapeutic failures attributed to medical management of cystic echinococcosis (CE) with albendazole (ABZ) have been primarily linked to the poor drug absorption rate resulting in low drug level in plasma and hydatid cysts.
In particular, the modulation of autophagy by HCV has been primarily linked to the activation of endoplasmic reticulum (ER) stress.
SMYD1, a gene that has been primarily linked to differentiation and embryogenesis of the heart, was recurrently mutated in our cohort.
Another main category, "communication difficulties", has been primarily linked to "hearing ability or disability", "lifestyle and relationship changes", and others' attitudes.
Elucidating the neurobiological mechanisms underlying these effects is critical, as pupil dilation has been primarily linked to LC-NE system activity, whereas reward motivation and positive emotion have been primarily associated with DA system influences.
