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The repeatability of the method has been previously validated, as well as the impact of misregistration on the generation of green and red clusters [26].
Hospital morbidity codes for brain, 7 coronary 8 and periphery 9 ischaemia have been previously validated, as have vascular deaths.
The device had been previously validated as an accurate way to distinguish sleep-wake patterns and generate a variety of sleep metrics.
First, because this variable has been previously validated as a proxy for non-cognitive skills related to the personality trait of conscientiousness and openness to experience (Hedengren and Stratmann 2012; Hitt et al. 2016; Cheng et al. 2016).
The combination of transaminases (ALT), biopsy, HBeAg and viral load have classically defined the inactive status of carriers of chronic hepatitis B. The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and necroinflammatory activity, has been previously validated as alternatives to biopsy.
9 miRNAs have been previously validated as functional activators or inhibitors of EMT or MET.
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We also evaluated the association of eight SNPs, which were previously validated as markers for DMR following IM therapy with MMR and CCyR parameters (Supplementary Tables 2–4).
The D50, D70, D90, maximum and average tumor dose (D avg), and V100 were calculated for each tumor since these metrics were previously validated as prognostic indices for radioembolization [9], where D50 and D90 are the minimum doses to 50 and 90% of tumor volume and V100 is the percentage of tumor volume receiving more than 100 Gy.
pFLuc TF reporter constructs were previously validated as described by the manufacturer [60].
This set of 40 indels was previously validated as useful in ancestry estimation through the study of the HGDP-CEPH Diversity Panel [12], which is composed of 1,064 individuals from 52 different worldwide populations distributed in seven geographical regions [11].
Thirty of the SNVs were previously validated as somatic by PCR and Sanger sequencing, and one had been shown to be a false positive.
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