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Consequently, a system's behavior can vary considerably compared to its well-mixed representation, a fact that has been previously shown through spatially-resolved models [ 1- 4].
It has been previously shown through in vitro studies that cyclin D1 can influence androgen-dependent prostate cancer cell proliferation through its dual ability to modulate both CDK4 and AR activity (Petre-Draviam et al, 2005; Burd et al, 2006a).
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Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through phosphatidylinositol-3 kinase (PI3K).
PP2A has been previously shown to reactivate GSK3β through dephosphorylation of Ser-9 [7], [7].
It has been previously shown that glucose metabolism through the PPP is neuroprotective because of its NADPH-regenerating function.
Some NALP proteins, for example, NALP12 and NALP6, have been previously shown to suppress inflammation through downregulation of NF-κB signaling subsequent to TLR activation [ 3].
It had been previously shown that Aβ resistant cells, through increased HIF-1 activity, modulate their cell metabolism to increase glucose uptake and glycolysis in the presence of Aβ [14].
Failure to adjust for clustering of outcomes in volume-outcome studies has been previously shown to lead to bias through an overestimation of the effect estimates.
The nuclear targeting peptide, an HIV-1 protein-derived TAT sequence, has been previously shown to aid entry of cargo through the cell membrane via normal cellular processes, and furthermore, to localize small cargo to the nucleus of the cell.
Postn stimulation has been previously shown to activate FAK and Akt through β3 or β4 integrin binding [ 16, 43, 44].
Hes1 has been previously shown to activate the p53 pathway through Mdm2; however, this probably requires specific cofactors because Hes1 cannot bind Mdm2 promoter per se (Huang et al., 2004).
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