Skeletal site-specific control of bone mass, both related and unrelated to the Wnt signaling pathway, has been previously observed [25], [41] [44], although the underlying mechanisms remain to be elucidated.
Such transcriptional up-regulation of the isoprenoid precursor pathways, which is likely to increase flux to terpenoid natural products [ 34], has been previously observed – e.g., in rice, although there only the MEP pathway was reported to be up-regulated by elicitation [ 35].
Divorce has been previously observed in S. mansoni [15], although its functional significance remains elusive.
The pvl phenotype has been previously observed in mutants defective for Wnt signaling although in this case it is thought to be a developmental defect [46].
Concerning TOSV, however, although seroconversion has been previously observed in patients in Greece, RNA has not been detected.
Although superinduction has been previously observed in the BG1Luc4E2 cell line [ 38], the molecular mechanism responsible for superinduction of ER-dependent gene expression in BG1Luc4E2 cells remains to be elucidated.
Reduced NA concentrations in the putamen, as well as frontal, temporal and occipital cortices of DLB patients compared to AD and control subjects have been previously observed by Ohara et al. [ 54], although no MHPG levels were measured and only five patients per group were included.
Similarly, trimethoprim-sulfamethoxazole (co-trimoxazole) can be an alternative treatment choice, particularly for non-multi-resistant MRSA infections, although emergence of resistance has been previously observed.
Although expected, this mechanism had not been previously observed because, as we discovered, the silencing resulting from direct inheritance of injected dsRNA is finite and depleted by 18 hours after injection.
Interestingly, although HP1 proteins themselves have not been previously observed at the centrosome/spindle pole, several HP1-interacting proteins are known to reside in this cell compartment.
