Phosphocholine metabolism has also been previously implicated with PC.
The present study supports the association of POAG a locus that has been previously implicated with vertical cup-disc ratio, a glaucoma-associated endophenotype.
Among the 31 miRNAs robustly associated with patient outcome were let-7g, miR-21, miR-1, and miR-138, all of which have been previously implicated with lung cancer survival [ 39, 41– 41].
None of the other listed AA substitutions (Table 2(c)) was previously implicated with replication, virulence, or pathogenicity markers.
HMGB1 has been previously implicated in CRC with controversial roles in cancer immunity and metastasis [ 44– 44].
These cell surface markers had been previously implicated to be of significant importance with CD150high cells enriching for HSCs with greater self-renewal (Beerman et al., 2010; Morita et al., 2010), and while genetic ablation of Sca-1 had no impact on HSC self-renewal (Bradfute et al., 2005), lower SPKLS cells were shown to have a higher Sca-1 expression (Challen et al., 2010).
SORCS1 has been previously implicated in neurodegeneration by genetic association with Alzheimer's disease as well as with APP processing whereby reduced expression of SORCS1 is associated with increased γ-secretase processing and Aβ levels possibly as a result of altered trafficking (28).
All three transcription factors we identify from Cusanovich et al. (2014) have been previously implicated in autoimmunity when cross-referenced with data from ImmunoBase (http://immunobase.org accessed April 3, 2014), providing validation of the method.
Nearly 25% of genes that showed altered expression compared with controls had been previously implicated in SCZD, although the expression profiling data also suggested that a number of pathways not previously implicated in SCZD might contribute to the disorder, such as Notch signaling, cell adhesion and Slit-Robo-mediated axon guidance.
Many genes associated with glutamateric neurotransmission have been previously implicated in schizophrenia, including GRM3, GRIN2A, SRR and GRIA1 [16].
Consistent with this notion, BRD4 has been previously implicated in the regulation of the stability of papillomavirus-encoded E2 protein.
