Estrogen, in particular, has been previously implicated as a modulator of GABAergic function [23].
Macrophages have been previously implicated as major players in antibody-dependent tumor control in vivo [26], [27].
Finding a role for Mad in segmentation was remarkable, because this process has been extensively studied in Drosophila genetic screens [25], [13] and Mad had not been previously implicated as part of the segmentation machinery.
Interestingly, all of the listed proteins have been previously implicated as cancer-related, and some have been suggested to be related to metastasis, including pyruvate kinase isozymes M1/M2 (PKM2), glucose transporter isoform 1 (GLUT1), macrophage migration inhibitory factor (MIF), peroxiredoxin-2 (PRDX2), L-lactate dehydrogenase A chain (LDHA), and heat shock protein HSP 90 alpha 2 (HSP90AA2).
It is noteworthy that both TOR and Hsf1 function have been previously implicated as being involved in aspects of cell wall integrity via effects on the PKC/Mpk1 cascade [54], [74], [75], and deletion of genes affecting cell wall integrity can affect rapamycin resistance, and potentially TOR [16].
Increases in plasma FFAs, similar to our findings, have been previously implicated as biomarkers of ageing.
A potential activator of that route would be the tri-peptide glutathione, which was previously implicated as a source for H2S (Rauhut 2008; Vos and Gray 1979).
The presence of this PDF projection was previously implicated as critical for the maintenance of free-running locomotor rhythms.
Interestingly, one of the detected mutations, a 2 bp insertion leading to a frameshift, occurred at the hit locus that was previously implicated as essential for host dependence in Bdellovibrio [14] (Figure 3).
miR-29 and miR-30 were previously implicated as potential tumor suppressor factors.
Motif searches on genomic regions identified by ChIP-seq analysis as potential enhancers reveal the recruitment of cell type-specific TFs that were previously implicated as essential regulators of lineage-specific differentiation.
