Similar priming effects were previously identified experimentally in leukaemias and ovarian cancers by quantifying the effects of pro-apoptotic BCL-2 peptides on MOMP and mitochondrial depolarisation.
All of these COGs were previously identified in the eight experimentally characterized T6SS, except the COG3157 which corresponds to the Hcp1 protein that is absent in the V. cholerae locus, albeit located elsewhere within its genome.
In all other eukaryotes, outside the kinetoplastids, DNA topoisomerase IB exists as a single fused protein, and the apparent fission in T. brucei was previously identified by sequencing and protein purification, and experimentally verified by catalytic activity characterisation of the protein pair, as well as genetic studies of essentiality of the genes encoding both subunits [ 34, 35].
The TRANSCompel® database contains 180 experimentally proven composite elements of two or more binding sites which were previously identified by individual wet lab studies from others.
In cotton, conserved miRNA targets were previously identified mainly via bioinformatics prediction [ 27] and only a few conserved miRNA targets have been experimentally validated [ 28].
One of them was previously identified as Capt.
However, there was no miRNAs being identified experimentally in C. sinensis.
Although many proteins are undoubtedly important for T. cruzi infection, surprisingly few have been identified experimentally.
Our motif collection encompasses 26 different DBD classes, and greatly increases the number and proportion of C. elegans TFs for which motifs have been identified experimentally, from 711010%) to 195 (26%) (five of the 129 had previously-known motifs).
By 2006, 1,627 (38%) of the 4,237 open reading frames (ORFs) had been identified experimentally.
