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Many conserved plant miRNAs have been previously identified, although relatively few have been well characterized [ 22, 29, 30].
These 60 SNP formed 33 DRB1 exon 2 alleles; two of which had not been previously identified; although both of them have been independently confirmed.
Alternatively, some specific tests are available for case-control studies when population stratification has been previously identified, although they can not be generalized to quantitative traits [ 33].
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6-hydroxy-6-methyl-3-heptanone has also been previously identified in mouse urine although we can find no report of this compound in human urine.
This type III system has not been previously identified in L. johnsonii and, although it does share amino acid identity with the restriction component of L. gasseri (90%) [11] and the modification component of Lactobacillus fermentum (55%) [44], the complete system does not have a close homolog in any sequenced LAB.
These dbSNPs have been previously identified for EGFR ([ 32]), although their functional significance is not yet known.
Pentamidine has also been previously identified as a promiscuously synergistic drug10, although the mechanisms underlying this promiscuity remain unknown.
Although MT1F has been previously identified as a marker for breast cancer, our study is unable to identify its association with breast cancer using the data from [ 27].
Other identified genes, such as Cbp/p300-interacting transactivator (CITED-1), hepatocyte growth factor receptor (c-MET), and various homeobox genes have yet to be investigated in melanoma although some have been previously identified in metastatic melanoma [ 11].
Although HMOX1 has been previously identified as being part of the network of TFEB-regulated genes, this is the first time that HMOX1 expression and oxidative stress have been directly linked to TFEB activity.
ADAMTS-4 is a pertinent enzyme in the pathogenesis of OA and although fibromodulin has been previously identified as a substrate for ADAMTS-4 [ 42], this was at the Tyr –Ala bond [ 43].
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